Resource Library

Our leadership in TPD is propelling the field forward.

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November 14, 2023

IRAK4 Degradation vs Inhibition

IRAK4 Program Background
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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July 24, 2023

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders

Gadiyar, V., Patel, G., Chen, J., Vigil, D., Ji, N., Campbell, V., Sharma, K., Shi, Y., Weiss, M., Birge, R., & Davra, V.
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December 7, 2022

Proteomics enabling TPD Drug Discovery

TPD Assay Development and Screening Summit
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October 25, 2022

Expression & Characterization of Novel Tissue Selective E3 Ligases

5th Annual Targeted Protein Degradation (TPD) Summit
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August 15, 2022

MQAtlas Creates a Deep, Accurate and Global E3 Expression Atlas Enabling Targeted Protein Degradation Based Precision Medicine

The 14th International Symposium on Mass Spectrometry in the Health and Life Sciences
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June 7, 2022

Discovery and characterization of IRAKIMiDs: degraders targeting both IRAK4 and IMiD substrates for oncology indications

Targeting protein degradation 3 – from discovery to the clinic (TPD3)
MYD88 Tumors
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June 6, 2022

Discovery and targeted mass spectrometry-based proteomics: Enabling technologies advancing IRAK4 protein degrader along the drug discovery pipeline into the clinic

The American Society for Mass Spectrometry (ASMS) Annual Conference
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May 31, 2022

STAT3 degraders inhibit Th17 development and cytokine production resulting in profound inhibition of collagen-induced autoimmune murine arthritis

European Alliance of Associations for Rheumatology (EULAR) 2022 Annual Congress
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May 17, 2022

Kinetics of IRAK4 Degradation and Impact on Functional Response in Circulating Immune Cells and Skin Cell Subsets

Society for Investigative Dermatology (SID) 2022 Annual Meeting
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May 10, 2022

Non-Clinical Safety Considerations when Developing Targeted Protein Degraders

Applied Pharmaceutical Toxicology (APT) 2022
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