Resource Library

Discover Kymera’s research and resources on our exciting platform, pipeline, and additional cutting-edge technologies.

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Related Resources


November 14, 2023

IRAK4 Degradation vs Inhibition

IRAK4 Program Background
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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November 13, 2023

Nature Medicine: IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, et al.
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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August 16, 2023

Discovery of KT-474, a potent, selective, and orally bioavailable IRAK4 degrader for the treatment of autoimmune diseases

American Chemical Society (ACS) Fall 2023 Meeting
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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May 18, 2023

Safety and Efficacy of IRAK4 Degrater KT-474 (SAR444656) for Hidradenitis Suppurativa and Atopic Dermatitis

European Academy of Dermatology & Venereology (EADV) Symposium 2023
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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October 26, 2022

The Phase 1 Healthy Volunteer Clinical Trial of KT-474

5th Annual Targeted Protein Degradation (TPD) Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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October 26, 2022

Development and Performance of Pharmacodynamic Assays to Demonstrate Proof-of-Mechanism for IRAK4 Degraders in a Phase1 Study

5th Annual Targeted Protein Degradation (TPD) Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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July 28, 2022

Utilizing degraders to Modulate B & T Cell Targets for Autoimmune Diseases

3rd B&T Cell-Mediated Autoimmune Disease Drug Development
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May 31, 2022

STAT3 degraders inhibit Th17 development and cytokine production resulting in profound inhibition of collagen-induced autoimmune murine arthritis

European Alliance of Associations for Rheumatology (EULAR) 2022 Annual Congress
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May 17, 2022

Kinetics of IRAK4 Degradation and Impact on Functional Response in Circulating Immune Cells and Skin Cell Subsets

Society for Investigative Dermatology (SID) 2022 Annual Meeting
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May 3, 2022

STAT3 Degraders Inhibit Cellular Activation, Cytokine Production, and Th17 Development, Resulting in Profound Inhibition of Autoimmunity in the MOG-EAE Model of CNS Inflammation

The American Association of Immunologists (AAI) Immunology2022(TM)
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