June 12, 2026
KT-621, an Oral, Once Daily STAT6 Degrader: Pharmacokinetics, Pharmacodynamics, and Safety in Healthy Japanese Adults
Japanese Dermatological Association (JDA) 2026
Healthy Volunteers
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June 11, 2026
Potent and Selective First-in-Class Oral IRF5 Degrader, KT-579, Inhibits Endosomal TLR-Induced Responses in SLE Derived PBMCs and Significantly Reduces Disease Activity in the MRL.lpr Mouse Lupus Model
Federation of Clinical Immunology Societies (FOCIS) 2026
Lupus
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June 6, 2026
First-in-class Oral IRF5 Degrader, KT-579, Demonstrates Selective and Potent In Vitro and In Vivo Activity in Human Cellular Assays and Mouse Models of Lupus
European Alliance of Associations for Rheumatology (EULAR) 2026
Lupus
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May 15, 2026
KT-621 Treatment Induces Rapid STAT6 Degradation and Modulation of Th2 Gene Transcripts in Atopic Dermatitis Lesional Skin
Society for Investigative Dermatology (SID) 2026 – Late Breaking Presentation
Atopic Dermatitis (AD)
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May 15, 2026
Revolutionizing Immunology with Oral Medicines
American Thoracic Society (ATS) - Respiratory Innovation Summit 2026
Asthma
Atopic Dermatitis (AD)
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May 5, 2026
Potent and Selective Oral IRF5 Degrader, KT-579, Demonstrates Robust Anti-Inflammatory Activity and Disease Modulation in Preclinical In Vivo Models of Inflammatory Bowel Disease
Digestive Disease Week (DDW) 2026
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March 28, 2026
Clinical Activity and Safety of KT-621, an Oral STAT6 Degrader, in Moderate-to-Severe Atopic Dermatitis: Phase 1b Trial Results
American Academy of Dermatology (AAD) 2026 – Late Breaking Presentation
Atopic Dermatitis (AD)
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January 13, 2026
Frontiers in Immunology: Targeted Degradation of MK2 is Insufficient to Block Inflammatory Cytokine Production in Human Cells Due to Cooperativity with MK3 and MK5
Yang, et al.
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December 12, 2025
Toxicological Sciences: Developmental Toxicology Profile of the IRAK4 Degrader KT-474
Enerson, et al.
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October 27, 2025
Potent and Selective Oral IRF5 Degrader, KT-579, Blocks Pro-Inflammatory Cytokines and Reduces Joint Swelling in Rodent Models of Rheumatoid Arthritis
American College of Rheumatology (ACR) 2025
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