Resource Library

Discover Kymera’s research and resources on our exciting platform, pipeline, and additional cutting-edge technologies.

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Related Resources

May 17, 2022

Kinetics of IRAK4 Degradation and Impact on Functional Response in Circulating Immune Cells and Skin Cell Subsets

Society for Investigative Dermatology (SID) 2022 Annual Meeting
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May 3, 2022

Selective IRAK4 Degradation, Not Kinase Inhibition, Blocks TLR-activated NF-kB and p38 Signaling Leading to broad Cytokine Inhibition

The American Association of Immunologists (AAI) Immunology2022(TM)
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May 3, 2022

STAT3 Degraders Inhibit Cellular Activation, Cytokine Production, and Th17 Development, Resulting in Profound Inhibition of Autoimmunity in the MOG-EAE Model of CNS Inflammation

The American Association of Immunologists (AAI) Immunology2022(TM)
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October 28, 2021

Considerations for E3 Ligase Pairing and Screening of Immune-Inflammation Targets

4th Annual TPD Summit
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October 27, 2021

Safety, PK and PD from Single Ascending Does Portion of KT-474 Phase 1 Trial in Healthy Volunteers

4th Annual TPD Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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October 26, 2021

TPD Workshop: De-risking Clinical Development of a Novel Protein Degrader

4th Annual TPD Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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September 21, 2021

Identification of Highly Potent and Selective Interleukin-1 Receptor Associates Kinase 4 (IRAK4) Degrader for the Treatment of Autoimmune Disease

European Protein Degradation Congress
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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May 10, 2021

IRAK4 Degradation Abrogates Cytokine Release and Improves Disease Endpoints in Murine Models of IL-33/36- as well as Th17-driven Inflammation

American Association of Immunologists’ Virtual IMMUNOLOGY2021™ Annual Meeting
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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May 3, 2021

Multiple Mediators of Inflammation Correlate with IRAK4 Expression in the Skin of Hidradenitis Suppurativa Patients and are Blocked by the IRAK4 Degrader KT-474 in TLR-activated Monocytes

Society for Investigative Dermatology (SID) 2021 Annual Meeting
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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November 3, 2020

IRAK4 Degrader to Take on Innate Immunity

Mullard, A. IRAK4 degrader to take on innate immunity. Nat Biotechnol 38, 1221–1223 (2020)
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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