Potent and Selective First-in-Class Oral IRF5 Degrader, KT-579, Inhibits Endosomal TLR-Induced Responses in SLE Derived PBMCs and Significantly Reduces Disease Activity in the MRL.lpr Mouse Lupus Model

Potent and Selective First-in-Class Oral IRF5 Degrader, KT-579, Inhibits Endosomal TLR-Induced Responses in SLE Derived PBMCs and Significantly Reduces Disease Activity in the MRL.lpr Mouse Lupus Model

Federation of Clinical Immunology Societies (FOCIS) 2026

Emily Lurier, Erik Corcoran, Virginia Massa, Jordan Leedberg, Yi Zhang, Ryan Camire, Chris Ho, Revonda Mehovic, Charles Howarth, Susanne Breitkopf, Sarah Martinez, Murugappan Sathappa, Juliet Williams, Nello Mainolfi, Veronica Campbell