May 10, 2021
IRAK4 Degradation Abrogates Cytokine Release and Improves Disease Endpoints in Murine Models of IL-33/36- as well as Th17-driven Inflammation
American Association of Immunologists’ Virtual IMMUNOLOGY2021™ Annual Meeting
Atopic Dermatitis (AD)
Hidradenitis Suppurativa (HS)
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May 3, 2021
Multiple Mediators of Inflammation Correlate with IRAK4 Expression in the Skin of Hidradenitis Suppurativa Patients and are Blocked by the IRAK4 Degrader KT-474 in TLR-activated Monocytes
Society for Investigative Dermatology (SID) 2021 Annual Meeting
Atopic Dermatitis (AD)
Hidradenitis Suppurativa (HS)
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April 10, 2021
Mechanisms Underlying Synergistic Activity of KT-413, a Targeted Degrader of IRAK4 and IMiD Substrates in Hematopoietic Cancers
American Association of Cancer Research (AACR) 2021 Annual Meeting
MYD88 Tumors
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February 16, 2021
Discovery of Potent and Selective STAT3 Targeted Protein Degraders with Excellent in vitro and in vivo ADME Properties
Oxford Global’s Virtual Symposium: Targeted Protein Degradation & PROTAC
Liquid Tumors
Solid Tumors
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February 16, 2021
Targeted Protein Degradation in Oncology and Beyond
2nd Annual North American Protein Degradation Congress
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December 7, 2020
KTX-120, A Novel IRAKIMiD Degrader of IRAK4 and IMiD Substrates, Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL Cell and Patient Derived Xenograft Models
62nd American Society of Hematology (ASH) Virtual Annual Meeting and Exposition
MYD88 Tumors
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December 7, 2020
Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations
62nd American Society of Hematology (ASH) Virtual Annual Meeting and Exposition
MYD88 Tumors
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December 7, 2020
Mechanisms of Anti-Tumor Activity of STAT3 Degraders in Lymphoma
62nd American Society of Hematology (ASH) Virtual Annual Meeting and Exposition
Liquid Tumors
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November 3, 2020
IRAK4 Degrader to Take on Innate Immunity
Mullard, A. IRAK4 degrader to take on innate immunity. Nat Biotechnol 38, 1221–1223 (2020)
Atopic Dermatitis (AD)
Hidradenitis Suppurativa (HS)
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October 15, 2020
Targeted Protein Degradation Beyond Oncology
3rd Annual Targeted Protein Degradation (TPD) Summit, Dr. Mainolfi
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