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The MDM2 degrader KTX-049 is highly potent in TP53 wild-type (p53 WT) Merkel cell carcinoma (MCC)

October 14, 2023

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics.

Kymera AACR NCI EORTC October 2023 Picture

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Area of Focus

Oncology

Programs

MDM2 (KT-253)

Indications

Solid Tumors

Development Stage

Pre-clinical Data

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June 6, 2023

Pulse Dosing of Potent and Selective Heterobifunctional MDM2 Degrader KT-253 Drives Tumor Regression and Demonstrates Differentiated Pharmacology Compared to p53/MDM2 Small Molecule Inhibitors

European Hematology Association (EHA) 2023 Hybrid Congress

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Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the treatment of Acute Myeloid Leukemia

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