Scientist, Targeted Proteomics
<h3><strong>Who we are:</strong></h3>
<p>Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit <a href="https://www.kymeratx.com" target="_blank">www.kymeratx.com</a> or follow us on <a href="https://twitter.com/KymeraTx?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor" target="_blank">X (formerly Twitter)</a> or <a href="http://www.linkedin.com/company/kymeratherapeutics" target="_blank">LinkedIn</a>. </p>
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<h3><strong>How we work:</strong></h3>
<ul>
<li><strong>PIONEER</strong>: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li>
<li><strong>COLLABORATE</strong>: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li>
<li><strong>BELONG</strong>: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li>
</ul>
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<h3><strong>How you’ll contribute:</strong></h3>
<ul>
<li>Develop, optimize, and implement targeted proteomics analysis workflows, including automated enrichment strategies, for precise, accurate, and sensitive protein measurements using stable isotope dilution and label-free mass spectrometry.</li>
<li>Coordinate with project teams to identify targeted proteomics assay requirements, timing, samples and deliverables.</li>
<li>Perform targeted protein MS assays using state-of-the-art LC-MS systems; including nano-LC, Orbitrap MS platforms to determine drug PD and quantify biomarkers for patient stratification and qualify assays for clinical studies.</li>
<li>Prepare samples from a wide variety of biological matrices (cultured cells, tissues, plasma, biofluids) from human and preclinical species using manual and automated bead-based workflows</li>
<li>Perform data analysis utilizing a range of proteomics software (Skyline, MaxQuant, DIANN, Spectronaut)</li>
<li>Maintain and qualify HPLC and MS instrument performance</li>
</ul>
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<h3><strong>Skills and experience you’ll bring:</strong></h3>
<ul>
<li>PhD in Biochemistry, Biology, Chemistry, Chemical Biology with minimally 2 years of experience in targeted mass spectrometry-based proteomics in industry or startup biotech setting or,</li>
<li>BS/MS with 8 + years of experience</li>
<li>Broad experience in targeted proteomics is required for:
<ul>
<li>Developing and deploying highly multiplexed and sensitive PRM stable isotope labeled peptide assays using DDA and DIA data</li>
<li>Maximizing protein recovery from a wide variety of complex sample matrices (cells, tissues, plasma, biofluids) and formulations (fresh, frozen, FFPE) across species</li>
<li>Operating, maintaining and troubleshooting nanoLC and Orbitrap MS instruments</li>
</ul>
</li>
<li>Demonstrated ability to independently analyze, and interpret targeted proteomics data</li>
<li>Organize and multitask efficiently to meet TPD drug discovery timelines</li>
<li>Communicate data and methodologies effectively in a fast paced, team-oriented environment</li>
<li>Familiarity with Regulatory filings, IND, clinical applications of Mass Spectrometry Assays</li>
<li>Working knowledge automated sample processing using lab automation, such as OpenTrons, is a plus.</li>
</ul>
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<p><strong><em><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak">Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.</span></em></strong></p>
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