Director, Immunology Translational Medicine
<h3><strong>Who we are:</strong></h3>
<p>Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit <a href="https://www.kymeratx.com" target="_blank">www.kymeratx.com</a> or follow us on <a href="https://twitter.com/KymeraTx?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor" target="_blank">X (formerly Twitter)</a> or <a href="http://www.linkedin.com/company/kymeratherapeutics" target="_blank">LinkedIn</a>. </p>
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<h3><strong>How we work:</strong></h3>
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<li><strong>PIONEER</strong>: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li>
<li><strong>COLLABORATE</strong>: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li>
<li><strong>BELONG</strong>: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li>
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<h3><strong>How you’ll contribute:</strong></h3>
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<li>Serve as an Immunology Translational Medicine Lead on cross-functional project team(s) and develop translational medicine and biomarker strategy from lead optimization through IND</li>
<li>Develop translational medicine strategies to support early portfolio assets</li>
<li>Collaborate with discovery team to vet potential ideas for target engagement and proof of mechanism markers</li>
<li>Collaborate with Medicine team to develop biomarker based PoC studies in appropriate patient populations</li>
<li>Work with clinical development team to oversee seamless implementation of translational assays in the clinic, and to review and interpret data and results</li>
<li>Develop and validate clinical assays at outsourced partner laboratories using multiple assay technology platforms (e.g., cell-based assays, molecular-based assays, single or multiplexed immunoassays, flow cytometry and/or imaging technologies)</li>
<li>Present translational medicine data packages internally and externally</li>
<li>Effectively coordinate with operational team to manage external collaborations with academic partners and CROs to deliver results on time and on budget</li>
<li>Review and author translational medicine sections of clinical documentation, including clinical protocols, study reports, consent forms; abstracts and/or manuscripts and regulatory documents (e.g. IND, IB etc.)</li>
<li>Drive internal translational medicine initiatives to support clinical understanding and advancement of clinical stage programs</li>
<li>Monitor developing biomarker approaches and incorporate novel technologies in support of ongoing and new clinical programs</li>
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<h3><strong>Skills and experience you’ll bring:</strong></h3>
<ul>
<li>PhD + 6 years of experience in translational science within the biotech/pharmaceutical industry</li>
<li>Demonstrated success leading translational medicine efforts for <em><u>immunology</u></em> drug development programs</li>
<li>Demonstrated experience delivering high quality clinical biomarker data to inform decisions and development strategy</li>
<li>Track record of working effectively with external experts in the Immunology space and CROs to design and execute studies</li>
<li>Demonstrated innovation in applying novel translational approaches to drug development</li>
<li>Strong leadership, communication, and cross-functional collaboration skills</li>
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<p><strong><em><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak">Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.</span></em></strong></p>
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