Senior Director or Executive Director, Toxicology
<h3><strong>Who we are:</strong></h3>
<p>Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit <a href="https://www.kymeratx.com" target="_blank">www.kymeratx.com</a> or follow us on <a href="https://twitter.com/KymeraTx?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor" target="_blank">X (formerly Twitter)</a> or <a href="http://www.linkedin.com/company/kymeratherapeutics" target="_blank">LinkedIn</a>. </p>
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<h3><strong>How we work:</strong></h3>
<ul>
<li><strong>PIONEER</strong>: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li>
<li><strong>COLLABORATE</strong>: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li>
<li><strong>BELONG</strong>: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li>
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<h3><strong>How you’ll make an impact:</strong></h3>
<p>We are seeking an experienced nonclinical toxicologist with small molecule drug development experience to join the Preclinical Development team at Kymera Therapeutics. The successful candidate will be responsible for overseeing the strategy, design, analysis, interpretation and reporting of Toxicology and Safety Pharmacology data for discovery and development teams. In addition, the individual will work with early discovery teams to develop preclinical safety strategies for new targets and support for programs in lead optimization and preclinical development.</p>
<ul>
<li>Provide expert nonclinical safety support, guidance, and strategy for Kymera’s degrader projects, ranging from discovery programs to advanced clinical programs
<ul>
<li>Act as the key nonclinical safety representative on cross-functional development teams contribute nonclinical safety-related scientific and regulatory expertise to drive integrated program decision-making.</li>
<li>Develop nonclinical safety strategies and plans for programs in all stages of drug development</li>
</ul>
</li>
<li>Oversee toxicology and safety pharmacology studies at multiple Contract Research Organizations
<ul>
<li>Design and execute GLP, non-GLP, investigative, and in vitro studies</li>
<li>With internal Study Monitor support, oversee toxicology studies for appropriate conduct, accuracy, and timely execution; review draft protocols and reports and ensure quality submission-ready documents for regulatory authorities</li>
</ul>
</li>
<li>Internal and external communication
<ul>
<li>Prepare verbal and written summaries for internal discussions. Work with the Preclinical Development team to develop optimal strategies to address specific safety issues and partner with project teams</li>
<li>Lead authorship of toxicology and/or safety pharmacology sections of various regulatory documents (e.g., pre-IND briefing documents, IND, IBs etc.)</li>
<li>Represent company at meetings with regulatory agencies</li>
<li>Present summary data to project teams and Kymera senior leadership</li>
</ul>
</li>
<li>Leadership
<ul>
<li>Provide leadership and mentorship to junior toxicology or preclinical staff as the team grows; foster a culture of scientific excellence</li>
</ul>
</li>
</ul>
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<h3><strong>Skills and experience you’ll bring:</strong></h3>
<ul>
<li>PhD in Toxicology or Pharmacology, DVM, or related field; DABT or ERT certification preferred, but not required</li>
<li>12+ years of experience in the biopharma industry in a Toxicology or Pathology role including ≥ 5 years supporting small molecule project teams leading preclinical development strategy for IND-through-Phase II programs.</li>
<li>Experience with EMA and FDA CTA/IND submissions and regulatory interactions</li>
<li>Experience partnering with internal stakeholders and colleagues to ensure comprehensive preclinical safety approaches are developed as part of the program strategy</li>
<li>Strong verbal and written communication skills with the ability to influence and present to executive leadership and external stakeholders, including regulatory agencies.</li>
<li>Experience working with outsourced studies</li>
<li>Ability to perform in fast-paced and dynamic environment</li>
</ul>
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<p><strong><em><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak">Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.</span></em></strong></p>
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