Scientist II or Senior Scientist, Pharmacology

<h3>Who we are:</h3> Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. For more information about our science, pipeline and people, please visit <a href="https://www.kymeratx.com" target="_blank">www.kymeratx.com</a> or follow us on <a href="https://twitter.com/KymeraTx?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor" target="_blank">X (formerly Twitter)</a> or <a href="http://www.linkedin.com/company/kymeratherapeutics" target="_blank">LinkedIn</a>.    <h3>How we work:</h3> <ul> <li>PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li> <li>COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li> <li>BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li> </ul>   <h3>How you’ll make an impact:</h3> We are looking for an experienced biologist to join the Cellular Pharmacology team at Kymera Therapeutics. The successful candidate will contribute to pipeline projects and help identify and validate new drug targets for inflammation and related therapeutic areas. This role involves generating high-quality data, analyzing results, and clearly communicating findings to project teams. Additionally, the candidate will review assay data from CROs to support lead discovery and characterization. <ul> <li>Design, perform, analyze, interpret, and report cellular and molecular assays for lead optimization and new target discovery projects.</li> <li>Apply standardization principles to assay design, quality control, analysis, and reporting in a drug discovery setting.</li> <li>Develop and validate primary cell-based assays—including those using whole blood, PBMCs, splenocytes, and other immune cells—and optimize these assays for scalability, reproducibility, and automation.</li> <li>Proactively identify and resolve technical and scientific challenges to ensure high-quality data and meet project timelines.</li> <li>Collaborate with cross-functional teams and present research findings in project meetings.</li> <li>Partner with CROs to advance assay development, transfer, and execution. Review external data for quality and ensure timely uploading to internal databases.</li> <li>Participate in evaluating targets and projects to continually advance the drug discovery pipeline and platform.</li> <li>Maintain accurate records of laboratory procedures and data.</li> </ul>   <h3>Skills and experience you’ll bring:</h3> <ul> <li>PhD in Immunology, molecular or cell biology, pharmacology, or a related field with more than two years of industry experience post-PhD. Candidates with an MS and extensive drug discovery experience will also be considered.</li> <li>Ability to apply biological insights to innovative assay design, development, and execution.</li> <li>Experience with diverse assay formats and modalities, such as RNA analysis (qPCR), endpoint (viability, apoptosis), phenotypic (live cell) assays, protein quantification (Western Blot, JESS, ELISA, MSD, HTRF, AlphaLisa, HIBIT), and protein-protein interaction assays (NanoBRET, NanoBiT).</li> <li>Extensive expertise in tissue culture with both immortalized cell lines and primary cells, including isolation, differentiation, and functional assays of immune cell subsets.</li> <li>A background in immunology is highly preferred.</li> <li>Familiarity with flow cytometry and gene editing techniques such as CRISPR/Cas9 is highly desirable.</li> <li>Experience with assay automation and scalability is a major asset.</li> <li>Proven ability to work collaboratively within project teams in a fast-paced environment.</li> <li>Excellent interpersonal and communication skills, with a strong team-oriented approach.</li> <li>Eagerness and ability to learn new skills and areas as required by project objectives.</li> <li> Experience collaborating with CROs and using electronic lab notebooks (ELN).</li> </ul>                                                                                                                                                                                 <div>Equal Employment Opportunity</div> Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.   Compensation <ul> <li>Kymera offers a competitive compensation package that recognizes both results and capabilities through market-based, performance-driven pay.</li> <li>The anticipated base salary range for this role is $90,000 – $200,000, with eligibility for annual bonus, equity participation, and comprehensive benefits.</li> <li>Actual salary is based on a holistic evaluation of the specific role/level as well as each candidate’s depth of experience and the capabilities they bring to the position.</li> </ul>

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