Kymera Therapeutics

Proteomics Scientist, Platform (Scientist to Senior Scientist)

Job Description:

We are seeking an enthusiastic, experienced proteomics scientist to join the Proteomics team at Kymera Therapeutics, contributing to projects which will accelerate drug discovery and advance new treatment options for patients with previously untreatable diseases. The Proteomics Scientist will employ multiple quantitative proteomics approaches to optimize analysis of deep proteomes and post-translational modifications, ensuring the production of high-quality proteomics data.


  • Develop and optimize sample preparation and mass spectrometry methods for analysis of deep proteomes and post-translational modifications using multiple quantitative proteomic approaches
  • Provide maintenance, quality control and troubleshooting of instruments, including HPLCs and mass spectrometers
  • Contribute to establishment of robust workflow of LC-MS-based proteomics and quantitative data analysis
  • Prepare samples from tissues, cells, and biofluids
  • Provide documentation, analysis, interpretation and presentation of experimental data in a clear and concise manner
  • Stay up-to-date on proteomics methods and technologies
  • Proactively recognize and solve technical and scientific issues to ensure high quality proteomics data is generated for the progression of drug discovery projects


  • Extensive hands-on experience in proteomics is required including
  • Maintaining and troubleshooting HPLCs and mass spectrometers
  • Developing methods and performing nano LC-MS/MS experiments using QE or Lumos mass spectrometers
  • Experience in multi-dimensional LC fractionation
  • Demonstrated ability to independently troubleshoot, analyze, and interpret proteomics data with attention to detail, to recommend and execute next steps
  • High level of proficiency in a variety of quantitative proteomics techniques -TMT, SILAC, label-free quantification approaches and peptide fragmentation methods
  • Experience with PTM analysis (phosphorylation and ubiquitination), protein interaction analysis, and targeted proteomics a plus
  • Extensive experience in protein isolation from complex biological samples including cells, tissue and biofluids and affinity enrichment to selectively enrich subproteomes
  • Experience with mammalian cell culture and molecular biology techniques a plus
  • Experience with automation and liquid handling systems a plus
  • Expertise in analysis of LC-MS/MS data using public and commercially available software
  • Experience with downstream statistical and bioinformatics analysis is a plus
  • Ability to conduct multiple laboratory and project tasks efficiently
  • Ability to work in a team-oriented environment
  • Attention to detail and strong record-keeping skills
  • Flexibility to rapidly adapt workplans to changing priorities and deadlines

Key Attributes:

Enthusiastic, goal-driven, collaborative and team-oriented, open-minded, creative, self-aware, excellent communication skills, proven strategic and people leadership skills


PhD in biochemistry, chemistry, biology, chemical biology or related discipline, with 5+ years quantitative mass spectrometry-based proteomics experience

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